Studies on the cell biological basis of increased reactivity in children with attention deficit/hyperactivity disorder and children with atopic dermatitis

Attention deficit / hyperactivity disorder (ADHD) is characterized by the leading symptoms inattention, impulsiveness and hyperactivity. ADHD children are significantly impaired in their educational, personal and social development. The etiopathogenesis is unclear. A meta-analysis with 170,175 patients demonstrated atopic dermatitis (AD) as an independently associated factor. Approximately 11% of the German population is affected by AD, 2% severely and chronically.

In a collaborative project with the University Clinic for Dermatology and Venereology, it was examined whether children with attention deficit/hyperactivity disorder (ADHD) and children with atopic dermatitis (AD) show comparable changes in the granular system of peripheral lympocytes. Initial data show elevated levels of eosinophils, IgE and ECP as well as similarities in granule release in both patient groups.

In the current project, it is to be examined whether methylphenidate, the most frequently used active substance in the treatment of ADHD, has an influence on the peripheral lymphocyte system.

Project leader: Prof. Dr. Hans-Henning Flechtner

Project manager: Martin Glemnitz, Wiebke Wölfer

Collaboration: PD Dr. Ambach, Universitätsklinik für Dermatologie und Venerologie, Universität Magdeburg; Prof. Dr. Gollnick, Universitätsklinik für Dermatologie und Venerologie, Universität Magdeburg

Duration: 01.09.2015 - 30.09.2017

Sponsor: Haushalt

If you have any questions regarding this project, please contact us: Wiebke Wölfer